Calcium Phosphate Bone Cements (CPCs) are an important step in the bioceramics sector. The possibility of having a calcium phosphate modelable pasta that can auto-thicken in vivo has significant benefits in many clinical situations such as osteoporotic fracture treatment, unstable fractures, facial malformations and maxillary deformities , And recently also in cases of specific applications such as vertebroplasty. 
CPCs are produced by the interaction process of two components, one solid state and one liquid state which, when mixed, form a paste that gradually thickens and hardens until reaching a solid mass state.  The bone cement thickening reaction represents a dissolution and precipitation process, while the aggregation of precipitated crystals results in the mechanism responsible for bone cement hardening. 
The versatility of this family of materials and their property of hardening at low temperatures makes them very interesting to use in combination with different techniques. These advantages are mostly related to the fact that the material consolidation is achieved by a dissolution reaction – low temperature precipitation which in some way reproduces the process that occurs in the biomineralization phenomena. This process allows to obtain hydrated compounds with a morphology and composition very similar to CaP (calcium phosphate) found inside mineralized tissues, having a high specific surface and a characteristic micro texture that can play a first role Plan in the phenomena of osteoinduction. 
Neocement® is a bone cement made up of hydroxyapatite based on synthetic calcium phosphate ceramic materials, for manual application. It consists of a solid component of tricalcium phosphate and tetra-calcium phosphate and a liquid component consisting of citric acid, glucose and chitosan.